| 产品编号 |
bs-46011P |
| 英文名称 |
Recombinant SARS-Cov-2 Spike RBD protein (N501Y), His (HEK293)
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| 中文名称 |
重组SARS冠状病毒2 Spike突变蛋白RBD(N501Y) (His Tag) |
| 别 名 |
SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2; 2019-nCOV Spike protein(N501Y), Recombinant (His Tag); Recombinant SARS-COV-2 S protein RBD (N501Y) Protein. ;Re 突变型新冠蛋白; 新冠病毒S蛋白突变体（N501Y）; 重组新冠病毒 Spike突变蛋白RBD(N501Y); 新型冠状病毒Spike突变体蛋白; |
| 理论分子量 |
26.2 kDa |
| 检测分子量 |
35 |
| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
＞0.5 mg/ml |
| 物 种 |
SARS-Cov-2 |
| 序 列 |
319-541/1273 |
| 纯 度 |
>95% as determined by SDS-PAGE |
| 纯化方法 |
AC |
| 内毒素 |
Not analyzed |
| 表达系统 |
HEK293 cell |
| 活性 |
Yes |
| 标签 |
His |
| 缓 冲 液 |
Lyophilized from 0.22um filtered solution in PBS (pH7.4). Normally 5% trehalose is added as protectant before lyophilization. |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In particular, the N501Y mutation is located at the receptor binding domain (RBD) of the spike protein.
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