david lyons edinburgh
We use zebrafish to dissect the molecular and cellular basis of nervous system development.
SC005336, VAT Registration Number GB 592 9507 00, and is acknowledged by the UK authorities as a Myelinated axons are essential for normal nervous system development and function, and disruption of the myelin sheath and associated axons is associated with many human diseases including Multiple Sclerosis (MS). Please also visit our home at the Centre for Discovery Brain Sciences, University of Edinburgh, and on the Zebrafish Information Network (ZFIN). Our lab uses zebrafish for two principle reasons: their amenability for live cell imaging and high-resolution cellular analyses, and their ability to be used to carry out large-scale genetic and chemical screens.
Myelinated axons are essential for normal nervous system development and function, and disruption of the myelin sheath and associated axons is associated with many human diseases including Multiple Scler… Our current focus is on elucidating mechanisms that orchestrate the formation of myelinated axons. Willingness to discuss research projects with undergraduate and postgraduate students: Individual neuronal subtypes exhibit diversity in CNS myelination mediated by synaptic vesicle release, Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination, Intersectional Gene Expression in Zebrafish Using the Split KalTA4 System, Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System, Synaptic Vesicle Release Regulates Myelin Sheath Number of Individual Oligodendrocytes In Vivo, Myelin Membrane Wrapping Of CNS Axons By PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue, On the Resemblance of Synapse Formation and CNS Myelination, Individual Oligodendrocytes Have Only A Few Hours in Which to Generate New Myelin Sheaths In Vivo, Axonal Selection and Myelin Sheath Generation in the Central Nervous System, Individual Axons Regulate the Myelinating Potential of Single Oligodendrocytes In Vivo, Freedom of information publication scheme, 2015 - present: Personal Chair of Neurobiology, Centre for Discovery Brain Sciences, 2014: Senior Research Fellowship from the Wellcome Trust, 2012: Award of a Research Prize from the Lister Institute, 2009: joined the Centre for Neuroregeneration through a BBSRC David Phillips Fellowship, 2004 - 2009: postdoctoral work at Stanford University in the Department of Developmental Biology with Prof. William Talbot, 2003: PhD in Developmental Biology, University College London, Koudelka S, Voas MG, Almeida RG, Baraban M, Soetaert J, Meyer MP, Talbot WS and. https://www.euanmacdonaldcentre.org/people/prof-david-lyons Unless explicitly stated otherwise, all material is copyright © The University of Edinburgh 2020. We use genetic screens, chemical screens, sophisticated imaging techniques, and electrophysiology in zebrafish to discover new genes with essential functions in myelinating glial cells, create better animal models of human disorders, and investigate potential novel therapies for diseases of the nervous system such as multiple sclerosis. These facts coupled with the relative simplicity of the early nervous system and the availability of transgenic lines that drive fluorescent reporters in a variety of cell types, make the zebrafish ideal for live in vivo imaging of entire developmental processes. 21 likes. David Lyons' Lab, Edinburgh, United Kingdom. David has 2 jobs listed on their profile. The Lyons group use zebrafish in their research to find strategies to understand how myelin is made and how it can be repaired in disease. Myelin, made by specialised glial cells, wraps around axons to regulate the speed of electrical transmission throughout our nervous system and to provide metabolic support.
He founded Farmer's Magazine (1800), took over the Scots Magazine (1801), founded the Edinburgh Review (1802) and obtained the publishing rights to the Encyclopædia Britannica (1812). We are delighted to congratulate Dave Lyons (CNR) on his promotion to Personal Chair. Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M. Nawaz S, Sánchez P, Schmitt S, Snaidero N, Mitkovski M, Velte C, Brückner BR, Alexopoulos I, Czopka T, Jung SY, Rhee JS, Janshoff A, Witke W, Schaap IAT, Mensch S, Baraban M, Czopka T, Ausborn J, El Manira A, and. David Lyons, 53, raised the defamation action against Strathclyde Police after he lost his MOT testing licence.
We are currently also embarking on a new forward genetic (gene discovery screen), using a transgenic reporter of myelination, to identify the molecular basis of central nervous system (CNS) myelination by oligodendrocytes in vivo, a process about which surprising little is known.
David Lyon was an actor with a remarkable versatility both for classic and contemporary plays. Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Almeida RG, Czopka, T, ffrench-Constant C, and. See the complete profile on LinkedIn and discover David… The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336, VAT Registration Number GB 592 9507 00. We combine our studies in zebrafish with analyses in other model systems, through our wide network of collaborators (see partners). The group of Prof. David Lyons study myelinated axons. Myelin allows the rapid propagation of information throughout our nervous system, and it is also essential for axon health. View David Lyons’ profile on LinkedIn, the world's largest professional community. Zebrafish embryos are transparent and undergo rapid early development (myelin is formed from just two days after egg fertilization).
We are currently using these approaches to study cell behaviour and cell-cell interactions during central nervous system myelination in vivo (see Publications below). Really fun to team up with Robin Franklin and Jonas Frisen @. processes. granted degree awarding powers.